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MK 2206 dihydrochloride

CAS No. 1032350-13-2

MK 2206 dihydrochloride ( MK-2206 dihydrochloride;MK2206 dihydrochloride )

Catalog No. M10155 CAS No. 1032350-13-2

A potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK 2206 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
  • Description
    A potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively; shows 5-fold less potent against human Akt3 (IC50=65 nM); synergistically inhibits cell proliferation of human cancer cell lines in combination with erlotinib or lapatinib in vitro; suppresses the Akt phosphorylation that is induced by carboplatin and gemcitabine.Colon Cancer Phase 2 Clinical
  • Synonyms
    MK-2206 dihydrochloride;MK2206 dihydrochloride
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt1;Akt2;Akt3
  • Research Area
    Cancer
  • Indication
    Colon Cancer

Chemical Information

  • CAS Number
    1032350-13-2
  • Formula Weight
    480.39
  • Molecular Formula
    C25H23Cl2N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO
  • SMILES
    Cl.Cl.NC1(CCC1)C1=CC=C(C=C1)C1=C(C=C2C3=NNC(=O)N3C=CC2=N1)C1=CC=CC=C1
  • Chemical Name
    1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hirai H, et al. Mol Cancer Ther. 2010 Jul;9(7):1956-67.
2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.
3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.
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