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MK 2206 dihydrochloride
CAS No. 1032350-13-2
MK 2206 dihydrochloride ( MK-2206 dihydrochloride;MK2206 dihydrochloride )
Catalog No. M10155 CAS No. 1032350-13-2
A potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 27 | In Stock |
|
| 5MG | 42 | In Stock |
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| 10MG | 58 | In Stock |
|
| 25MG | 87 | In Stock |
|
| 50MG | 132 | In Stock |
|
| 100MG | 205 | In Stock |
|
| 200MG | 335 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK 2206 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively.
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DescriptionA potent, orally active allosteric Akt inhibitor with IC50 of 5/12 nM for Akt1/Akt2 respectively; shows 5-fold less potent against human Akt3 (IC50=65 nM); synergistically inhibits cell proliferation of human cancer cell lines in combination with erlotinib or lapatinib in vitro; suppresses the Akt phosphorylation that is induced by carboplatin and gemcitabine.Colon Cancer Phase 2 Clinical
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SynonymsMK-2206 dihydrochloride;MK2206 dihydrochloride
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt1;Akt2;Akt3
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Research AreaCancer
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IndicationColon Cancer
Chemical Information
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CAS Number1032350-13-2
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Formula Weight480.39
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Molecular FormulaC25H23Cl2N5O
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESCl.Cl.NC1(CCC1)C1=CC=C(C=C1)C1=C(C=C2C3=NNC(=O)N3C=CC2=N1)C1=CC=CC=C1
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Chemical Name1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hirai H, et al. Mol Cancer Ther. 2010 Jul;9(7):1956-67.
2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.
3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.
2. Cheng Y, et al. Mol Cancer Ther. 2012 Jan;11(1):154-64.
3. Whicker ME, et al. BMC Cancer. 2016 Jul 27;16:550.
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